UMass Boston

Circadian Rhythms, Fungal Genomics, Transcriptomics, Genetics, Molecular Biology

PhD, Duke University, Program in Genetics & Genomics (2017)
BS, Gettysburg College, Biochemistry & Molecular Biology (2011)

• Kelliher CM, Stevenson EL, Loros JJ, Dunlap JC. 2023. Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability. PLoS Biology. 21(1): e3001961. PMID: 36603054. doi: 10.1371/journal.pbio.3001961.
• Kelliher CM, Lambreghts R, Xiang Q, Baker CL, Loros JJ, Dunlap JC. 2020. PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock. Elife. 9: e64007. PMID: 33295874. doi: 10.7554/eLife.64007.
• Kelliher CM, Loros JJ, Dunlap JC. 2020. Evaluating the circadian rhythm and response to glucose addition in dispersed growth cultures of Neurospora crassa. Fungal Biology. 124(5): p. 398-406. PMID: 32389302. doi: 10.1016/j.funbio.2019.11.004.
• Smith LM, Motta FC, Chopra G, Moch JK, Nerem RR, Cummins B, Roche KE, Kelliher CM, Leman AR, Harer J, Gedeon T, Waters NC, Haase SB. 2020. An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum. Science. 368(6492): p. 754-759. PMID: 32409472. doi: 10.1126/science.aba4357.
• Kelliher CM, Foster MW, Motta FC, Deckard A, Soderblom EJ, Moseley MA, Haase SB. 2018. Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae. Molecular Biology of the Cell. 29(22): p. 2644-2655. PMID: 30207828. doi: 10.1091/mbc.E18-04-0255.
• Kelliher CM, Leman AR, Sierra CS, Haase SB. 2016. Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans. PLoS Genetics. 12(12): e1006453. PMID: 27918582. doi: 10.1371/journal.pgen.1006453.
• McGoff KA, Guo X, Deckard A, Kelliher CM, Leman AR, Francey LJ, Hogenesch JB, Haase SB, Harer JL. 2016. The Local Edge Machine: inference of dynamic models of gene regulation. Genome Biology. 17(1): p. 214. PMID: 27760556. doi: 10.1186/s13059-016-1076-z.

Research Interests

The Kelliher Lab is investigating the circadian clock, the biological process that most organisms on planet Earth use to tell time. The circadian clock allows an organism to optimally align behavior with the 24-hour light/dark cycle. In our research, we use the fungal model organism Neurospora crassa as well as genetic, genomic, biochemical, and computational tools. The lab is currently pursuing mechanisms of cross-talk between the circadian clock and the nutrient environment and also pursuing gene regulatory mechanisms of a key circadian kinase. Please visit our lab website (http://kelliherlab.com) for full details about our work and for research opportunities in the Kelliher Lab.

Honors

• 2018 – 2022: Ruth L. Kirschstein National Research Service Award (F32GM128252)
• 2022: Society for Research on Biological Rhythms (SRBR) Merit Award
• 2021: Neurospora Perkins Award